Stereoselective access to trisubstituted fluorinated alkenyl thioethers

Catalysis Science & Technology 2017,7, 1921-1927

DOI: 10.1039/C7CY00076F

We report the first copper-catalyzed olefinic ethoxy carbonyl difluoromethylation of alkenyl thioethers via direct C–H bond functionalization using BrCF2COOEt. The developed methodology allows the preparation of trisubstituted olefins with a controlled stereochemistry. A mechanistic study is reported and a radical mechanism is revealed.